bs-5986R-HRP [Conjugated Primary Antibody]
AIM2 Polyclonal Antibody, HRP Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: AIM2

Immunogen Range: 255-354/354


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 383619

Swiss Prot: Q91VJ1

Source: KLH conjugated synthetic peptide derived from mouse AIM2

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8.

Conjugation: HRP

Excitation/ Emission: N/A

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)

Predicted Molecular Weight: 40


Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Yuan B et al. Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage. Cell Death Dis. 2020 Jan 30;11(1):76.Read more>>
  • Yuan B et al. Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage. Cell Death Dis. 2020 Jan 30;11(1):76.Read more>>
  • Pardes Habibet al. Gonadal Hormones E2 and P Mitigate Cerebral Ischemia-Induced Upregulation of the AIM2 and NLRC4 Inflammasomes in Rats. Int J Mol Sci. 2020 Jul 7;21(13):4795.Read more>>
  • Elizaveta S. Ershova. et al. In Vitro Analysis of Biological Activity of Circulating Cell-Free DNA Isolated from Blood Plasma of Schizophrenic Patients and Healthy Controls. Genes-Basel. 2022 Mar;13(3):551Read more>>
  • Eren Arik. et al. Erythropoietin Enhances Post-ischemic Migration and Phagocytosis and Alleviates the Activation of Inflammasomes in Human Microglial Cells. FRONT CELL NEUROSCI. 2022; 16: 915348Read more>>
  • Pikria Ketelauri. et al. Acute Circadian Disruption Due to Constant Light Promotes Caspase 1 Activation in the Mouse Hippocampus. CELLS-BASEL. 2023 Jan;12(14):1836Read more>>
  • Shichijo Kazuko. et al. Radiation makes cells select the form of death dependent on external or internal exposure: apoptosis or pyroptosis. SCI REP-UK. 2023 Jul;13(1):1-12Read more>>
  • Li Danyang. et al. Identification of Pyroptosis-Related Genes Regulating the Progression of Chronic Rhinosinusitis with Nasal Polyps. INT ARCH ALLERGY IMM. 2024 Feb;:1-14Read more>>
VALIDATION IMAGES