bs-60040C

DATASHEET

Formulation powder

Storage: Store in dry, dark place at -20C for 1 year.

Product Information:

Molecular Weight: 306.4

Formula: C20 H22 N2 O

CAS Number: 425399-05-9

InChi Key: RXIUMAOXORBRCY-UHFFFAOYSA-N

InChi: InChI=1S/C20H22N2O/c23-12-11-21-19-8-4-7-16-17-13-15(14-5-2-1-3-6-14)9-10-18(17)22-20(16)19/h1-3,5-6,9-10,13,19,21-23H,4,7-8,11-12H2

Smiles: OCCNC1CCCC2=C1NC1=CC=C(C=C21)C1C=CC=CC=1

Purity: 98.0

Solubility: DMSO up to 100 mM

Appearance: Solid Power.

Shelf Life: 1.0 years

Description:

CASIN is a novel and potent Cdc42 inhibitor with an IC50 ~2 µM. In a recent publication in Cell Stem Cell, the elevated activity of the small RhoGTPase Cdc42 in aged HSCs was shown to be causally linked to HSC aging and correlate with a loss of polarity in aged HSCs. CASIN as a specific inhibitor of Cdc42 was shown to functionally rejuvenate aged HSCs, increase the percentage of polarized cells in an aged HSC population, and restore the level and spatial distribution of histone H4 lysine 16 acetylation to a status similar to that seen in young HSCs. CASIN-treated HSCs were further shown to engraft long term in vivo with enhanced repopulation ability.