bs-60087C

DATASHEET

Formulation powder

Storage: Store in dry, dark place at -20C for 1 year.

Product Information:

Molecular Weight: 350.44

Formula: C19 H18 N4 O S

CAS Number: 315703-52-7

InChi Key: ROYXIPOUVGDTAO-UHFFFAOYSA-N

InChi: InChI=1S/C19H18N4OS/c1-3-24-15-9-7-14(8-10-15)21-19-22-16(12-25-19)18-13(2)20-17-6-4-5-11-23(17)18/h4-12H,3H2,1-2H3,(H,21,22)

Smiles: CC1N=C2C=CC=CN2C=1C1=CSC(NC2=CC=C(C=C2)OCC)=N1

Purity: 98.0

Solubility: DMSO up to 100mM

Appearance: Solid Power.

Shelf Life: 1.0 years

Description:

JK184 is a potent and cell-permeable inhibitor of hedgehog (Hh) signaling downstream of Smo, identified by a cell-based Hh pathway reporter screening. JK184 was found to inhibit Adh7 (IC50 ~210 nM), the class IV alcohol dehydrogenase as well as act as a microtubule depolymerizing agent in vitro. JK184 inhibits Hh agonit-induced Gli transcriptional activity (IC50 ~30 nM) as well as Gli1 and Ptc1 mRNA expression in a dose-dependent manner in 10T1/2 cells. It shows antiproliferative activity in a range of cancer cell lines (IC50 ~ 3 - 21 nM), and inhibits the growth of two xenografted tumors in mice in vivo.