bs-60136C

DATASHEET

Formulation powder

Storage: Store in dry, dark place at -20C for 1 year.

Product Information:

Molecular Weight: 420.52

Formula: C24 H24 N2 O3 S

CAS Number: 222716-34-9

InChi Key: JKIXLEKBXHMXTN-UHFFFAOYSA-N

InChi: InChI=1S/C24H24N2O3S/c1-2-15-12-16-22(28)18(24-25-19-8-4-5-9-20(19)30-24)14-29-23(16)17(21(15)27)13-26-10-6-3-7-11-26/h4-5,8-9,12,14,27H,2-3,6-7,10-11,13H2,1H3

Smiles: CCC1C=C2C(=O)C(=COC2=C(CN2CCCCC2)C=1O)C1=NC2C=CC=CC=2S1

Purity: 98.0

Solubility: DMSO up to 50 mM

Appearance: Solid Power.

Shelf Life: 1.0 years

Description:

SKP2-C25 is a potent, selective and cell permeable Skp2 inhibitor. It selectively inhibits Skp2 E3 ligase activity, but not activity of other SCF complexes. It also phenocopies the effects observed upon genetic Skp2 deficiency, such as suppressing survival and Akt-mediated glycolysis and triggering p53-independent cellular senescence. SKP2-C25 exhibits potent antitumor activities in multiple animal models and cooperates with chemotherapeutic agents to reduce cancer cell survival. It is a useful chemical probe to target Skp2, which is a promising target for restricting cancer stem cell and cancer progression.