bs-60222C
[Life Science]
OF-1 --- BRPF Bromodomain Inhibitor
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support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 440.31
Formula: C17 H18 Br N3 O4 S
CAS Number: 919973-83-4
InChi Key: YUNQZQREIHWDQT-UHFFFAOYSA-N
InChi: InChI=1S/C17H18BrN3O4S/c1-10-7-11(18)5-6-16(10)26(23,24)19-12-8-13-14(9-15(12)25-4)21(3)17(22)20(13)2/h5-9,19H,1-4H3
Smiles: CC1C=C(Br)C=CC=1S(=O)(=O)NC1=CC2=C(C=C1OC)N(C)C(=O)N2C
Purity: 98.0
Solubility: DMSO up to 20 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C17 H18 Br N3 O4 S
CAS Number: 919973-83-4
InChi Key: YUNQZQREIHWDQT-UHFFFAOYSA-N
InChi: InChI=1S/C17H18BrN3O4S/c1-10-7-11(18)5-6-16(10)26(23,24)19-12-8-13-14(9-15(12)25-4)21(3)17(22)20(13)2/h5-9,19H,1-4H3
Smiles: CC1C=C(Br)C=CC=1S(=O)(=O)NC1=CC2=C(C=C1OC)N(C)C(=O)N2C
Purity: 98.0
Solubility: DMSO up to 20 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
OF-1 is the potent and selective BRPF (BRomodomain and PHD Finger containing) inhibitor. It binds to BRPF1B with a KD of 100 nM (ITC), to BRPF2 with a KD of 500 nM (ITC) and to BRPF3 with a KD of 2.4 mM (ITC). It has general >100-fold selectivity against other bromodomains (39-fold selectivity over BRD4). OF-1 increases thermal stability in the cellular thermal shift assay (CETSA) of full length BRPF1B at 1 µM and also demonstrates accelerated FRAP recovery at 5 µM in the BRPF2 FRAP assay. It shows modest general cytotoxicity.
Size: 10mg, 2mg
Applications: Life Science
For research use only. Not intended for diagnostic or therapeutic use.