bs-60288C
[Life Science]
1, 4-DPCA --- Prolyl 4-hydroxylase (P4H) Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 240.21
Formula: C13 H8 N2 O3
CAS Number: 331830-20-7
InChi Key: XZZHOJONZJQARN-UHFFFAOYSA-N
InChi: InChI=1S/C13H8N2O3/c16-12-8-4-3-7-2-1-5-14-10(7)11(8)15-6-9(12)13(17)18/h1-6H,(H,15,16)(H,17,18)
Smiles: OC(=O)C1=CNC2C(=CC=C3C=CC=NC3=2)C1=O
Purity: 98.0
Solubility: DMSO up to 10 mM, EtOH up to 20 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C13 H8 N2 O3
CAS Number: 331830-20-7
InChi Key: XZZHOJONZJQARN-UHFFFAOYSA-N
InChi: InChI=1S/C13H8N2O3/c16-12-8-4-3-7-2-1-5-14-10(7)11(8)15-6-9(12)13(17)18/h1-6H,(H,15,16)(H,17,18)
Smiles: OC(=O)C1=CNC2C(=CC=C3C=CC=NC3=2)C1=O
Purity: 98.0
Solubility: DMSO up to 10 mM, EtOH up to 20 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
1, 4-DPCA is a selective and cell permeable prolyl 4-hydroxylase (P4H) inhibitor. It inhibits α-prolyl4-hydroxylase, an oxygen-sensing enzyme that targets the pro-angiogenic factor HIF-1α for destruction upon hydroxylation of a specific proline residue. It also inhibits asparaginyl-hydroxylase factor inhibiting HIF (FIH) and is useful for controlling excess collagen deposition in pathological fibrosis.
Size: 2 mg solid, 10mg solid2 mg solid, 10mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.