bs-60291C
[Life Science]
1-methyl-D-tryptophan (D-1MT) --- IDO Inhibitor
DATASHEET
Formulation Powder
Storage: Powder: 4C for 2 year, -20C for 3 years
Product Information:
Molecular Weight: 218.25
Formula: C12 H14 N2 O2
CAS Number: 110117-83-4
InChi Key: ZADWXFSZEAPBJS-SNVBAGLBSA-N
InChi: InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m1/s1
Smiles: CN1C=C(C[C@@H](N)C(O)=O)C2=CC=CC=C12
Purity: 98.0
Solubility: H2O : 5 mg/mL (22.91 mM; ultrasonic and adjust pH to 2 with HCl), 5 mM (warming); DMSO : 0.55 mg/mL (2.52 mM; Need ultrasonic and warming).
Appearance: White to off-white solid powder
Shelf Life: 3.0 years
Formula: C12 H14 N2 O2
CAS Number: 110117-83-4
InChi Key: ZADWXFSZEAPBJS-SNVBAGLBSA-N
InChi: InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m1/s1
Smiles: CN1C=C(C[C@@H](N)C(O)=O)C2=CC=CC=C12
Purity: 98.0
Solubility: H2O : 5 mg/mL (22.91 mM; ultrasonic and adjust pH to 2 with HCl), 5 mM (warming); DMSO : 0.55 mg/mL (2.52 mM; Need ultrasonic and warming).
Appearance: White to off-white solid powder
Shelf Life: 3.0 years
Description:
1-methyl-D-tryptophan (D-1MT) is a potent and selective indoleamine 2, 3-dioxygenase (IDO) inhibitor with IC50 ~7 μM. It disrupts tryptophan catabolism and enhances the antitumor and antiviral immunoresponses of CD8+ T-cells in vitro. It can reduce tumor volume in mice with xenografts overexpressing IDO.
Size: 2 mg solid, 10mg solid2 mg solid, 10mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.