bs-60417C

DATASHEET

Formulation powder

Storage: Store in dry, dark place at -20C for 1 year.

Product Information:

Molecular Weight: 326.35

Formula: C17 H18 N4 O3

CAS Number: 956590-23-1

InChi Key: WCKZRLOUKYFJDY-UHFFFAOYSA-N

InChi: InChI=1S/C17H18N4O3/c1-20(2)6-7-21-15(22)12-5-3-4-10-8-11(19-17(18)24)9-13(14(10)12)16(21)23/h3-5,8-9H,6-7H2,1-2H3,(H3,18,19,24)

Smiles: CN(C)CCN1C(=O)C2=CC=CC3C=C(C=C(C=32)C1=O)NC(N)=O

Purity: 98.0

Solubility: DMSO: 21.5 mg/mL

Appearance: Solid Power.

Shelf Life: 1.0 years

Description:

UNBS5162 is a novel naphthalimide that binds to DNA by intercalation and suppresses CXCL chemokine elaboration. In vivo UNBS5162 after repeat administration significantly increased survival in orthotopic human prostate cancer models. Results obtained by the National Cancer Institute (NCI) using UNBS3157 and UNBS5162 against the NCI 60 cell line panel did not show a correlation with any other compound present in the NCI database, including amonafide, thereby suggesting a unique mechanism of action for these two novel naphthalimides.