bs-6184R [Primary Antibody]
Renin Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Renin

Immunogen Range: 331-406/406


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 5972

Swiss Prot: P00797

Source: KLH conjugated synthetic peptide derived from human Renin

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 37


Cross Reactive Species: Mouse
Rat
Dog

Predicted Cross Reactive Species: Human
Cow
Horse

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Wanka, Heike, et al. "Anti-necrotic and cardioprotective effects of a cytosolic renin isoform under ischemia-related conditions." Journal of Molecular Medicine(2015): 1-9.Read more>>
  • Liu, Chen, et al. "Pulmonary artery denervation improves pulmonary arterial hypertension induced right ventricular dysfunction by modulating the local renin-angiotensin-aldosterone system." BMC Cardiovascular Disorders 16.1 (2016): 192.Read more>>
  • Wu, Ka, et al. "Biocharacterization of Heat Shock Protein 90 in Acetaminophen-Treated Livers Without Conspicuous Drug Induced Liver Injury." Cellular Physiology and Biochemistry 43.4 (2017): 1-1.Read more>>
  • Soto et al. Exposure to fine particulate matter in the air alters placental structure and the renin-angiotensin system. (2017) PLoS.One. 12:e0183314Read more>>
  • R Sun et al. Calcimimetic R568 reduced the blood pressure and improved aortic remodeling in spontaneously hypertensive rats by inhibiting local renin‑angiotensin system activity.(2018),Experimental and Therapeutic Medicine. 16: 4089-4099Read more>>
  • Xu X et al. Potential biomarker of fibroblast growth factor 21 in valproic acid-treated livers. Biofactors. 2019 May 23. Read more>>
  • Chen ZZ et al. Tanshinone IIA contributes to the pathogenesis of endometriosis via renin angiotensin system by regulating the dorsal root ganglion axon sprouting. Life Sci. 2019 Nov 20;240:117085.Read more>>
  • Jiamei Yao. et al. Comparative transcriptomic analysis revealed novel potential therapeutic targets of traditional Chinese medicine (Pinggan-Qianyang decoction) on vascular remodeling in spontaneously hypertensive rats. Chin Med-Uk. 2021 Dec;16(1):1-17Read more>>
  • Yongli Zhao. et al. Calcilytic NPS2143 promotes proliferation and inhibits apoptosis of spontaneously hypertensive rat vascular smooth muscle cells via activation of the renin?angiotensin system. Exp Ther Med. 2020 Aug;20(2):818-829Read more>>
VALIDATION IMAGES

Lane 1: Mouse Kidney Lysates; Lane 2: Rat Kidney Lysates. Probed with Renin polyclonal Antibody, unconjugated (bs-6184R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.