bs-6309R-BF405 [Conjugated Primary Antibody]
IL-6 Polyclonal Antibody, AbBy Fluor® 405 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: IL-6

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 16193

Source: KLH conjugated synthetic peptide derived from mouse IL-6

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

IL6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. It acts upon a variety of cells including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. In addition, IL6 appears to interact with IL2 in the proliferation of T lymphocytes. IL6 potentiates the proliferative effect of IL3 on multipotential hematopoietic progenitors.

Conjugation: AbBy Fluor® 405

Excitation/ Emission: 401nm/421nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)

Cross Reactive Species: Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Xu et al. Extracts of Bauhinia championii (Benth.) Benth. attenuate the inflammatory response in a rat model of collagen-induced arthritis. (2016) Mol.Med.Re. 13:4167-74Read more>>
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  • Jia-xiang Zhang. et al. Kupffer cell depletion attenuates IL-6/STAT3 mediates hepatocyte apoptosis in immunological liver injury of trichloroethylene sensitized mice. Int Immunopharmacol. 2020 Nov;88:106897Read more>>
  • Yudan Zhao. et al. COX-2 is required to mediate crosstalk of ROS-dependent activation of MAPK/NF-_B signaling with pro-inflammatory response and defense-related NO enhancement during challenge of macrophage-like cell line with Giardia duodenalis. PLOS NEGLECT TROP D. 2022 Apr;16(4):e0010402Read more>>
  • Zhang Peng. et al. Study on the Mechanism of Bu-Shen-He-Mai Granules in Improving Renal Damage of Ageing Spontaneously Hypertensive Rats by Regulating Th17 Cell/Tregs Balance. EVID-BASED COMPL ALT. 2022;2022:8315503Read more>>
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  • Ren, Xiaoli. et al. Expression and significance of IL-6 and IL-8 in canine mammary gland tumors. SCI REP-UK. 2023 Jan;13(1):1-9Read more>>
  • Zhan Xie. et al. A novel model of subretinal edema induced by DL-alpha aminoadipic acid. EXP EYE RES. 2023 Jan;:109388Read more>>
  • Guo Dongming. et al. IGF2 inhibits hippocampal over-activated microglia and alleviates depression-like behavior in LPS- treated male mice. BRAIN RES BULL. 2023 JaRead more>>
  • Liping Han. et al. Weierning, a Chinese patent medicine, improves chronic atrophic gastritis with intestinal metaplasia. J ETHNOPHARMACOL. 2023 Jun;309:116345Read more>>
  • Min Zhou. et al. Electroacupuncture at Fengchi(GB20) and Yanglingquan(GB34) Ameliorates Paralgesia through Microglia-Mediated Neuroinflammation in a Rat Model of Migraine. BRAIN SCI. 2023 Apr;13(4):541Read more>>
  • Panhong Wu. et al. Interleukin-17A knockout or self-recovery alleviated autoimmune reaction induced by fluoride in mouse testis. SCI TOTAL ENVIRON. 2023 Apr;:163616Read more>>
  • Tianying Hong. et al. Jatrorrhizine inhibits Piezo1 activation and reduces vascular inflammation in endothelial cells. BIOMED PHARMACOTHER. 2023 Jul;163:114755Read more>>
  • Yuting Zhang. et al. Ginkgo biloba extract attenuates cisplatin-induced renal interstitial fibrosis by inhibiting the activation of renal fibroblasts through down-regulating the HIF-1/STAT3/IL-6 pathway in renal tubular epithelial cells. PHYTOMEDICINE. 2023 Apr;:154809Read more>>
  • Ming-Xin Sun. et al. Aristolochic acid I exposure triggers ovarian dysfunction by activating NLRP3 inflammasome and affecting mitochondrial homeostasis. FREE RADICAL BIO MED. 2023 MayRead more>>
  • Xuewen Duan. et al. IRG1 prevents excessive inflammatory responses and cardiac dysfunction after myocardial injury. BIOCHEM PHARMACOL. 2023 Jul;213:115614Read more>>
  • Xiangjie Fu. et al. Synergistic and Long-Lasting Wound Dressings Promote Multidrug-Resistant Staphylococcus Aureus-Infected Wound Healing. INT J NANOMED. 2023 Aug 16Read more>>
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  • Tian-Bao Wang. et al. Rosmarinic acid mitigates acrylamide induced neurotoxicity via suppressing endoplasmic reticulum stress and inflammation in mouse hippocampus. PHYTOMEDICINE. 2024 Apr;126:155448Read more>>
  • Jinhong Cai. et al. Multifunctional PDA/ZIF8 based hydrogel dressing modulates the microenvironment to accelerate chronic wound healing by ROS scavenging and macrophage polarization. CHEM ENG J. 2024 Mar;:150632Read more>>
  • Wang Wei. et al. Cayratia albifolia C.L.Li exerts anti-rheumatoid arthritis effect by inhibiting macrophage activation and neutrophil extracellular traps (NETs). CHIN MED-UK. 2024 Dec;19(1):1-13Read more>>
  • Yue-Ming Zhang. et al. Mitochondrial antioxidant elamipretide improves learning and memory impairment induced by chronic sleep deprivation in mice. BRAIN BEHAV. 2024 Apr;14(5):e3508Read more>>
  • Shuang Li. et al. Protective Effect of Prunella vulgaris L. Whole ?Plant or Spicas Water Extracts on Hyperthyroidism with Liver-yang Hyperactivity Syndrome. PHARMACOGN MAG. ;()Read more>>
  • Changyuan He. et al. A hyaluronic acid hydrogel as a mild photothermal antibacterial, antioxidant, and nitric oxide release platform for diabetic wound healing. J CONTROL RELEASE. 2024 Jun;370:543Read more>>
  • Yan Yunji. et al. Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-B pathways. CELL COMMUN SIGNAL. 2024 Dec;22(1):1-13Read more>>
  • Xian Ding. et al. Sevoflurane enhances autophagy via Rac1 to attenuate lung ischaemiareperfusion injury. CHEM-BIOL INTERACT. 2024 Jul;397:111078Read more>>
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  • Yingying Wang. et al. Linderae Radix extract attenuates ulcerative colitis by inhibiting the JAK/STAT signaling pathway. PHYTOMEDICINE. 2024 Jul;:155868Read more>>
VALIDATION IMAGES