bs-6321R [Primary Antibody]
WISP1 Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: WISP1

Immunogen Range: 237-295/367


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 8840

Swiss Prot: O95388

Source: KLH conjugated synthetic peptide derived from human WISP1

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.

Size: 100ul

Concentration: 1ug/ul

Applications: ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 38


Cross Reactive Species: Mouse

Predicted Cross Reactive Species: Human
Rat
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Xu, Wei, et al. "Resveratrol Attenuates Hyperoxia‐induced Oxidative Stress, Inflammation and Fibrosis and Suppresses Wnt/β‐catenin Signaling in Lungs of Neonatal Rats." Clinical and Experimental Pharmacology and Physiology(2015).Read more>>
  • Chunyu Zhang et al. WISP1 promotes bovine MDSC differentiation via recruitment of ANXA1 for the regulation of the TGF- signalling pathway. Mol Cell Biochem. 2020 Jul;470(1-2):215-227.Read more>>
  • Sensen Lv. et al. LncRNA NEAT1 Knockdown Alleviates Lipopolysaccharide-Induced Acute Lung Injury by Modulation of miR-182-5p/WISP1 Axis. 2021 May 27Read more>>
  • Jinhao Zeng. et al. Ginsenoside Rb1 Lessens Gastric Precancerous Lesions by Interfering With -Catenin/TCF4 Interaction. Front Pharmacol. 2021; 12: 682713Read more>>
VALIDATION IMAGES

Formalin-fixed and paraffin embedded mouse kidney labeled with Rabbit Anti WISP1 Polyclonal Antibody, Unconjugated (bs-6321R) at 1:200 followed by conjugation to the secondary antibody and DAB staining