bs-6803C

DATASHEET

Formulation Powder

Storage: Store in dry, dark place at -20C for 1 year.

Product Information:

Molecular Weight: 427.32

Formula: C18 H17 Cl2 F N4 O S

CAS Number: 1047644-62-1

InChi Key: AFJRDFWMXUECEW-LBPRGKRZSA-N

InChi: InChI=1S/C18H17Cl2FN4OS/c1-25-16(14(19)9-23-25)13-7-15(27-17(13)20)18(26)24-12(8-22)6-10-3-2-4-11(21)5-10/h2-5,7,9,12H,6,8,22H2,1H3,(H,24,26)/t12-/m0/s1

Smiles: CN1N=CC(Cl)=C1C1C=C(SC=1Cl)C(=O)N[C@H](CN)CC1=CC(F)=CC=C1

Purity: 98.0

Solubility: Soluble in DMSO, not in water

Appearance: Solid Power.

Shelf Life: 1.0 years

Description:

Afuresertib, also known as GSK-2110183 or GSK-2110183C, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Afuresertib binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis