bs-6855R-A647

DATASHEET

Host: Rabbit

Target Protein: NALP4

Specificity: This antibody will detect multiple forms of NALP4, including the A, C and E Mouse variants.

Immunogen Range: 351-450/994

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 147945

Swiss Prot: Q96MN2

Source: KLH conjugated synthetic peptide derived from human NALP4

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.

Conjugation: ALEXA FLUOR® 647

Excitation/ Emission: 650nm/665nm

Size: 100ul

Concentration: 1ug/ul

Applications: IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 113

Cross Reactive Species: Human
Rat

Predicted Cross Reactive Species: Mouse
Pig
Horse

For research use only. Not intended for diagnostic or therapeutic use.