bs-6978C
[Life Science]
NE 52-QQ57
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support@biossusa.com
800.501.7654 [DOMESTIC]
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support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 416.52
Formula: C24 H28 N6 O
CAS Number: 1401728-56-0
InChi Key: HXPQWNPLNIEJOW-UHFFFAOYSA-N
InChi: InChI=1S/C24H28N6O/c1-4-21-20(22-26-15(2)13-16(3)30(22)29-21)14-17-5-7-18(8-6-17)23-27-28-24(31-23)19-9-11-25-12-10-19/h5-8,13,19,25H,4,9-12,14H2,1-3H3
Smiles: CCC1=NN2C(N=C(C)C=C2C)=C1CC1C=CC(=CC=1)C1=NN=C(O1)C1CCNCC1
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C24 H28 N6 O
CAS Number: 1401728-56-0
InChi Key: HXPQWNPLNIEJOW-UHFFFAOYSA-N
InChi: InChI=1S/C24H28N6O/c1-4-21-20(22-26-15(2)13-16(3)30(22)29-21)14-17-5-7-18(8-6-17)23-27-28-24(31-23)19-9-11-25-12-10-19/h5-8,13,19,25H,4,9-12,14H2,1-3H3
Smiles: CCC1=NN2C(N=C(C)C=C2C)=C1CC1C=CC(=CC=1)C1=NN=C(O1)C1CCNCC1
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
NE52-QQ57 is an orally available GPR4 antagonist with an IC50 of 70 nM. NE 52-QQ57 significantly inhibited the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE2).
Size: 10mg, 2mg
Applications: Life Science
For research use only. Not intended for diagnostic or therapeutic use.