bs-6982R-Cy3 [Conjugated Primary Antibody]
Neutrophil Elastase Polyclonal Antibody, Cy3 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Neutrophil Elastase

Immunogen Range: 101-200/267


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1991

Swiss Prot: P08246

Source: KLH conjugated synthetic peptide derived from human Neutrophil Elastase

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.

Conjugation: Cy3

Excitation/ Emission: 512,550nm/570,615nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
FCM(1:20-100)
IF(IHC-P)(1:50-200)

Predicted Molecular Weight: 26


Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Jeffery, Unity, et al. "Dogs Cast NETs too: Canine neutrophil extracellular traps in health and immune-mediated hemolytic anemia." Veterinary Immunology and Immunopathology (2015).Read more>>
  • Arecco, N., et al. "Elastase levels and activity are increased in dystrophic muscle and impair myoblast cell survival, proliferation and differentiation."Scientific Reports 6 (2016): 24708.Read more>>
  • Maekawa, Toshihiro, et al. "Prophylactic Effect of Lactobacillus pentosus strain S-PT84 on Candida Infection and Gastric Inflammation in a Murine Gastrointestinal Candidiasis Model [Errata]." Medical mycology journal 57.4 (2016): E81-E92.Read more>>
  • Li, Guofu, et al. "The neutrophil elastase inhibitor, sivelestat, attenuates sepsis-related kidney injury in rats." International Journal of Molecular Medicine 38.3 (2016): 767-775.Read more>>
  • Krishnan, Subramanian, et al. "Serotype O18 avian pathogenic and neonatal meningitis Escherichia coli strains employ similar pathogenic strategies for the onset of meningitis." Virulence 6.8 (2015): 777-786.Read more>>
  • Peng et al. Adiponectin and adiponectin receptor 1 overexpression enhance inflammatory bowel disease. (2018) J.Biomed.Sci. 25:24Read more>>
  • Arecco et al. Elastase levels and activity are increased in dystrophic muscle and impair myoblast cell survival, proliferation and differentiation. (2016) Sci.Rep. 6:24708Read more>>
  • Ye, Y. et al. CXCR1/CXCR2 antagonist G31P inhibits nephritis in a mouse model of uric acid nephropathy.(2018) BIOMED PHARMACOTHERRead more>>
  • Störmann P et al. Contributing factors in the development of acute lung injury in a murine double hit model. Eur J Trauma Emerg Surg. 2019 Apr 1.Read more>>
  • Wang H et al. The effect of exposure time and concentration of airborne PM2. 5 on lung injury in mice: A transcriptome analysis. Redox Biol. 2019 Jul 2;26:101264. Read more>>
  • Gao J et al. Metformin protects against PM2. 5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase α2. Redox Biol. 2019 Oct 19;28:101345.Read more>>
  • Vaibhav K et al. Neutrophil extracellular traps exacerbate neurological deficits after traumatic brain injury. Sci Adv.2020 May 29;6(22):eaax8847.Read more>>
  • Sladjana Skopelja-Gardner. et al. Acute skin exposure to ultraviolet light triggers neutrophil-mediated kidney inflammation. P Natl Acad Sci Usa. 2021 Jan;118(3)Read more>>
  • Andrew R. Sas. et al. A new neutrophil subset promotes CNS neuron survival and axon regeneration. Nat Immunol. 2020 Oct;21(12):1496-1505Read more>>
  • Qin Tan. et al. Periodontitis pathogen Porphyromonas gingivalis promotes pancreatic tumorigenesis via neutrophil elastase from tumor-associated neutrophils. GUT MICROBES. 2022;14(1):2073785Read more>>
  • Yongcan Wu. et al. Probiotics ameliorates pulmonary inflammation via modulating gut microbiota and rectifying Th17/Treg imbalance in a rat model of PM2.5 induced lung injury. ECOTOX ENVIRON SAFE. 2022 Oct;244:11406Read more>>
  • Cao Yirui. et al. Formyl peptide receptor 2 activation by mitochondrial formyl peptides stimulates the neutrophil proinflammatory response via the ERK pathway and exacerbates ischemiaCreperfusion injury. CELL MOL BIOL LETT. 2023 Dec;28(1):1-24Read more>>
  • Li Xiangdong. et al. Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3. J TRANSL MED. 2023 Dec;21(1):1-19Read more>>
  • Hannah M. Lunnemann. et al. Cecum axis (CecAx) preservation reveals physiological and pathological gradients in mouse gastrointestinal epithelium. GUT MICROBES. 2023;15(1):Article: 2185029Read more>>
  • Luchen Sun. et al. A novel mesenchymal stem cell-based regimen for acute myeloid leukemia differentiation therapy. ACTA PHARM SIN B. 2023 MayRead more>>
  • Fanshuai Meng. et al. Impact of age on liver damage, inflammation, and molecular signaling pathways in response to femoral fracture and hemorrhage. FRONT IMMUNOL. 2023; 14: 1239145Read more>>
VALIDATION IMAGES