bs-70015R

DATASHEET

Host: Rabbit

Target Protein: Amyloid Precursor Protein

Specificity: Specific for endogenous levels of the ~115 kDa APP protein. Immunolabeling of the APP protein band is completely blocked by preadsorption of the antibody with the peptide used as antigen.

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 54226

Swiss Prot: P08592

Source: Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat APP, conjugated to keyhole limpet hemocyanin (KLH).

Purification: Antigen Affinity purification from Pooled whole antiserum

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

A large body of evidence has implicated the amyloid precursor protein (APP) in the pathogenesis of Alzheimer's disease (AD) (Kamenetz et al., 2003). The phosphorylation of APP at Thr668 is thought to play a critical role in generation of the soluble APP (beta) and beta-amyloid peptide (abeta) which are the major components of senile plaques in patient brains inflicted with AD (Liu et al., 2003; Ando et al., 2001).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 115

Cross Reactive Species: Mouse
Rat

Predicted Cross Reactive Species: Human
Dog
Chicken
Non-Human Primate

For research use only. Not intended for diagnostic or therapeutic use.