bs-70111R

DATASHEET

Host: Rabbit

Target Protein: GABAB Receptor (Ser783), R2-Subunit

Specificity: Specific for endogenous levels of the ~102 kDa GABAB R2 phosphorylated at Ser783. Immunolabeling is completely eliminated by treatment with λ-phosphatase.

Modification Site: Ser783

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 83633

Swiss Prot: O88871

Source: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser783 of the R2 subunit of rat GABAB recerptor, conjugated to keyhole limpet hemocyanin (KLH).

Purification: Antigen Affinity purification from Pooled whole antiserum

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABA-A and the GABA-B subtype of receptors. GABA-B receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. It has recently been demonstrated that AMPK binds directly to GABA-B receptors and phosphorylates Ser-783 in the cytoplasmic tail of the R2 subunit and that Ser-783 plays a critical role in enhancing neuronal survival after ischemia as phosphorylation of Ser-783 is evident in many brain regions and is increased dramatically after ischemic injury to the brain (Kuramoto et al., 2007).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 102

Cross Reactive Species: Mouse
Rat

Predicted Cross Reactive Species: Human
Dog
Bovine
Chicken
Xenopus
Non-Human Primate

For research use only. Not intended for diagnostic or therapeutic use.