bs-70114R [Primary Antibody]
GABA Transporter (GAT) 2 Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
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DATASHEET

Host: Rabbit

Target Protein: GABA Transporter (GAT) 2

Specificity: Specific for endogenous levels of the ~82 kDa GAT-2 protein.

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 171163

Swiss Prot: P31646

Source: Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat GAT2, conjugated to keyhole limpet hemocyanin (KLH).

Purification: Affinity purification

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABA-A receptor (GABA-A-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-2 is found in a wide range of neuronal and non-neuronal cells including dendrites and axon terminals as well as epithelial cells and cells forming the pia and arachnoid complex (Conti et al., 1999)

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 67


Cross Reactive Species: Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.