bs-70118R

DATASHEET

Host: Rabbit

Target Protein: Glial Fibrillary Acidic Proetin (GFAP)

Specificity: Specific for endogenous levels of the ~50 kDa GFAP protein. A lower band at ~45 kDa is a proteolytic fragment derived from the GFAP molecule.

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 281189

Swiss Prot: P14136

Source: Recombinant human GFAP.

Purification: Neat whole antiserum

Storage Buffer: Neat whole antiserum

Storage: Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliq

Background:

Glial Fibrillary Acidic Protein (GFAP) was discovered by Amico Bignami and co-workers as a major fibrous protein of multiple sclerosis plaques (1). It was subsequently found to be a member of the 10nm or intermediate filament (IF) family, specifically the IF family Class III, which also includes peripherin, desmin and vimentin. GFAP is strongly and specifically expressed in astrocytes and certain other astroglia in the CNS, in satellite cells, peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In many damage and disease states GFAP expression is heavily upregulated in astrocytes. In addition, neural stem cells frequently strongly express GFAP. Point mutations in the protein coding region of the GFAP gene lead to Alexander disease which is characterized by the presence of abnormal astrocytes containing GFAP protein aggregates known as Rosenthal fibers (2).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 50

Cross Reactive Species: Human
Mouse
Rat
Bovine
Horse

For research use only. Not intended for diagnostic or therapeutic use.