bs-70206R

DATASHEET

Host: Rabbit

Target Protein: Olig2

Specificity: Specific for endogenous levels of the ~32 kDa Olig2 protein.

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 50913

Swiss Prot: Q9EQW6

Source: Recombinant mouse Olig2.

Purification: Purified by Protein A.

Storage Buffer: 100 mM Glycine, 200 mM Tris, pH 8.0

Storage: Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliq

Background:

Olig2 is a transcription factor which is required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Expressed in the ventral spinal cord as early as 9.5 dpc and scattered in the mantle zone, likely corresponding to oligodendrocyte progenitors migrating out from their site of origin. From 10.5 through 14.5 dpc, Olig2 is expressed in numerous cells in the ventricular and subventricular zones of the lateral and medial ganglionic eminences, suggesting that expression might not be limited to the oligodendrocytic lineage. Olig2 has further been shown to be critical in the proliferation of malignant glioma in brain tumors (Ligon et al., 2007)

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 27

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.