bs-70218R

DATASHEET

Host: Rabbit

Target Protein: PEBP (phosphatidylethanolamie binding protein)

Specificity: Specific for endogenous levels of the ~22 kDa PEBP protein.

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 31042

Swiss Prot: P31044

Source: Purified native rat PEBP

Purification: Neat whole antiserum

Storage Buffer: Neat whole antiserum

Storage: Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cy

Background:

Phosphatidylethanolamine binding protein (PEBP), also known as Raf kinase inhibitory protein (RKIP) is a highly conserved multifunctional protein that modulates the Raf/MAPK signaling cascade and has been implicated as a suppressor of metastatic cancer (Trakul N et al., 2005). PEBP has been shown to not only inhibit cell proliferation but also to induce differentiation of human keratinocytes (Yamazaki et al., 2004). Dysregulation of calpain activity results in cellular degeneration in conditions such as Alzheimer’s disease and recently PEBP has been identified as a potential in vivo calpain substrate (Chen at al., 2006).

Size: 100uL

Concentration: Lot Dependent

Applications: WB(1:300-5000)

Predicted Molecular Weight: 22

Cross Reactive Species: Rat

For research use only. Not intended for diagnostic or therapeutic use.