bs-70263R

DATASHEET

Host: Rabbit

Target Protein: Stargazin

Specificity: Specific for endogenous levels of the ~36kDa stargazin protein. Immunolabeling of the stargazin band is blocked by preadsorption with the peptide used as antigen.

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 12300

Swiss Prot: O88602

Source: Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat Stargazin, conjugated to keyhole limpet hemocyanin (KLH).

Purification: Antigen Affinity purification from Pooled whole antiserum

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

Stargazin is a member of the transmembrane AMPAR regulatory proteins (TARP) family and is involved in glutamate receptor trafficking. It has been recently demonstrated (Tomita et al., 2005; Priel et al., 2005) that the interaction between stargazin and AMPA receptors is critical for the correct localization of the receptors at the synapse. Phosphorylation of the stargazin protein at Thr-321- by Protein Kinase A regulates its interaction with PSD-95 and synaptic targeting of AMPA receptors (Choi et al., 2002).

Size: 100uL

Concentration: Lot Dependent

Applications: WB(1:300-5000)

Predicted Molecular Weight: 36

Cross Reactive Species: Rat

Predicted Cross Reactive Species: Mouse

For research use only. Not intended for diagnostic or therapeutic use.