bs-70265R

DATASHEET

Host: Rabbit

Target Protein: Synapsin I

Specificity: Specific for endogenous levels of the ~78 kDa synapsin I doublet. Immunolabeling blocked by preadsorption of antibody with the protein used to generate the antibody.

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 281510

Swiss Prot: P17599

Source: Native protein purified from bovine brain.

Purification: Antigen Affinity purification from Pooled whole antiserum

Storage Buffer: Lyophilized

Storage: Reconstitute in 50 ul phosphate buffered saline (PBS: 137 mM NaCl, 7.5 mM Na2HPO4, 2.7 mM KCl, 1.5 mM KH2PO4, pH 7.4) before use. After reconstitution it is recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial d

Background:

Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002; Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. In addition to its role in plasticity, the expression of synapsin I is a precise indicator of synapse formation (Moore and Bernstein, 1989; Stone et al., 1994). Thus, synapsin I immunocytochemistry provides a valuable tool for the study of synaptogenesis. The role of synapsin in synaptic plasticity and in synaptogenesis is regulated by phosphorylation (Jovanovic et al., 2001; Kao et al., 2002).

Size: 10ug

Concentration: Lot dependent

Applications: WB(1:300-5000)
IP(1-2ug)

Predicted Molecular Weight: 78

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.