bs-70270R

DATASHEET

Host: Rabbit

Target Protein: Synapsin I (Ser603)

Specificity: Specific for endogenous levels of the ~78 kDa synapsin I doublet phosphorylated at Ser603 . Immunolabeling is completely eliminated by treatment with λ-phosphatase.

Modification Site: Ser603

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 281510

Swiss Prot: P17599

Source: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser603 of rat synapsin, conjugated to keyhole limpet hemocyanin (KLH).

Purification: Antigen Affinity purification from Pooled whole antiserum

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002; Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogenesis regulated by phosphorylation (Jovanovic et al., 2001; Kao et al., 2002). Serine 603 is the site on synapsin I that is phosphorylated by calcium calmodulin kinase II and by p21-activated kinases (Sakurada et al., 2002; Czernik et al., 1987). Phosphorylation of this site is thought to regulate synaptic vesicle function (Nayak et al., 1996; Bahler and Greengard, 1987; McGuinness et al., 1989).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 78

Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Bovine
Zebrafish
Xenopus

For research use only. Not intended for diagnostic or therapeutic use.