bs-7086C
[Life Science]
CCF-642
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support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 378.45
Formula: C15 H10 N2 O4 S3
CAS Number: 346640-08-2
InChi Key: SPYIETQLOVDJCF-WQLSENKSSA-N
InChi: InChI=1S/C15H10N2O4S3/c1-21-10-4-2-9(3-5-10)16-14(18)12(24-15(16)22)8-11-6-7-13(23-11)17(19)20/h2-8H,1H3/b12-8-
Smiles: COC1C=CC(=CC=1)N1C(=S)SC(=CC2=CC=C(S2)[N+]([O-])=O)C1=O
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C15 H10 N2 O4 S3
CAS Number: 346640-08-2
InChi Key: SPYIETQLOVDJCF-WQLSENKSSA-N
InChi: InChI=1S/C15H10N2O4S3/c1-21-10-4-2-9(3-5-10)16-14(18)12(24-15(16)22)8-11-6-7-13(23-11)17(19)20/h2-8H,1H3/b12-8-
Smiles: COC1C=CC(=CC=1)N1C(=S)SC(=CC2=CC=C(S2)[N+]([O-])=O)C1=O
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
CCF-642 is a protein disulfide isomerase (PDI) inhibitor. CCF642 exhibited a submicromolar IC50 in 10 of 10 multiple myeloma cell lines. In vitro, CCF642 inhibited PDI reductase activity about 100-fold more potently than the structurally distinct established inhibitors PACMA 31 and LOC14. CCF642 displayed potent efficacy in an aggressive syngeneic mouse model of multiple myeloma and prolonged the lifespan of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma, an effect comparable to the first-line multiple myeloma therapeutic bortezomib.
Size: 10mg, 2mg
Applications: Life Science
For research use only. Not intended for diagnostic or therapeutic use.