bs-7140C

DATASHEET

Formulation powder

Storage: Store in dry, dark place at -20C for 1 year.

Product Information:

Molecular Weight: 487.5

Formula: C28 H36 Cl2 N2 O

CAS Number: 67469-81-2

InChi Key: NQWRSILGEXNJIT-UHFFFAOYSA-N

InChi: InChI=1S/C28H34N2O.2ClH/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27;;/h1-9,11-12,14-17,28H,10,13,18-24H2;2*1H

Smiles: Cl.Cl.C(CCN1CCN(CCOC(C2C=CC=CC=2)C2C=CC=CC=2)CC1)C1C=CC=CC=1

Purity: 98.0

Solubility: Soluble in DMSO

Appearance: Solid Power.

Shelf Life: 1.0 years

Description:

GBR-12935 is a piperazine derivative which is a potent and selective dopamine reuptake inhibitor. It was originally developed in its 3H radiolabelled form for the purpose of mapping the distribution of dopaminergic neurons in the brain by selective labelling of dopamine transporter proteins. This has led to potential clinical uses in the diagnosis of Parkinson's disease, although selective radioligands such as Ioflupane (¹²³I) are now available for this application. GBR-12935 is now widely used in animal research into Parkinson's disease and the dopamine pathways in the brain.