bs-75034C

DATASHEET

Formulation Powder

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 501-36-0

Molecular formula: C14H12O3

Molecular weight: 228.2

Purity: >98% (HPLC)

Appearance: Off-white to greyish powder.

Solubility: Soluble in DMSO, ethanol or DMF. Slightly soluble in water or PBS.

InChiKey: LUKBXSAWLPMMSZ-OWOJBTEDSA-N

SMILES: OC1=CC=C(\C=C\C2=CC(O)=CC(O)=C2)C=C1

Description:

Potent phenolic antioxidant found in grapes and red wine [1, 19]. Eicosanoid synthesis and platelet aggregation inhibitor [2]. Estrogen receptor agonist [3]. Chemopreventive [4, 15]. Specific inhibitor of cyclooxygenase-1 (COX-1) [4]. Anti-inflammatory [4, 21]. Ribonucleotide reductase and DNA synthesis [5]. Arrests cell cycle at S/G2 phase [6, 23]. Anticancer and antiproliferative compound [7, 16]. Apoptosis inducer [8, 23]. Protein kinase D inhibitor. Does not inhibit PKC [9]. Autophagy inducer [10, 23]. Potent SIRT1 (sirtuin 1) activator [11, 22]. Neuroprotective [12, 18]. Adipogenesis inhibitor [13]. PGC-1alpha activator [14]. Sonic hedgehog (Shh) signaling pathway modulator. Gli1 mRNA expression inhibitor. Downregulates Gli transcriptional activity [17]. Cardioprotective [19, 21]. Anti-diabetic [20]. Senescence modulator. Extends lifespan [22]. Inhibitor of NLRP3 inflammasome activation [24].