bs-75335C

DATASHEET

Formulation Solid

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 76684-89-4

Molecular formula: C15H26N2O5

Molecular weight: 314.4

Purity: >98% (HPLC)

Appearance: White solid.

Solubility: Soluble in DMSO (10mg/ml) or ethanol (10mg/ml). Slightly soluble in water (1mg/ml).

InChiKey: SCMSYZJDIQPSDI-QJPTWQEYSA-N

SMILES: O=C(O)[C@H]1[C@H](C(N[C@@H](CC(C)C)C(NCCC(C)C)=O)=O)O1

Description:

E-64c is a potent cell-impermeable epoxysuccinyl peptide inhibitor of calpain and other cysteine proteases, such as papain, cathepsin B, H and L. Does not inhibit the serine proteases trypsin, chymotrypsin or elastase. E-64c is an active metabolite of the protease inhibitor E-64d (Prod. No. bs-75618C), and a synthetic analog of E-64 (Prod. No. bs-75334C). Studies indicate that E-64c is a more potent inhibitor of cathepsins B and L compared to E-64. E-64c has in vitro antiviral, antiparasitic and immunomodulatory properties. It reduces the autocatalytic activity of the foot-and-mouth-disease virus (FMDV) leader protease, reduces infection of HEK293T cells by an HIV-based virus system pseudotyped with SARS-CoV spike glycoprotein in a concentration-dependent manner, inhibits human rotavirus replication, and exhibits entry-blocking effects against MERS-CoV. It also inhibits the trypanosomal cysteine protease cruzain. Significantly reduces calpain-mediated depletion of microtubule-associated protein (MAP2) in an animal model of an ischemic brain.