bs-75643C

DATASHEET

Formulation Solid

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: n.d.

Molecular formula: C19H26N6O

Molecular weight: 354.5

Purity: >98% (NMR)

Appearance: White to off-white solid.

Solubility: Soluble in DMSO or ethanol.

InChiKey: HYFZLABHJHEEFS-CQSZACIVSA-N

SMILES: CC[C@H](CO)NC1=NC2=C(N=CN2C(C)C)C(=N1)N(C)C1=CC=CC=C1

Description:

Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Abeta42 and decreases production of extracellular Abeta38 in cultured cells. Extracellular Abeta40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting gamma-secretase activity toward Abeta42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds).