bs-75947C
[Life Science]
(-)-Bicuculline methiodide
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support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation Powder
Storage: Stable for 2 years after receipt when stored at +4°C.
Product Information:
CAS Number: 40709-69-1
Molecular formula: C21H20INO6
Molecular weight: 509.29
Purity: >95% (NMR)
Appearance: White to off-white powder.
Solubility: Soluble in water (10 mg/ml) or DMSO (30mg/ml).
InChiKey: HKJKCPKPSSVUHY-GRTNUQQKSA-M
SMILES: C[N+]1(C)[C@@]([C@@]2([H])C(C=CC3=C4OCO3)=C4C(O2)=O)([H])C5=CC6=C(OCO6)C=C5CC1.[I-]
Molecular formula: C21H20INO6
Molecular weight: 509.29
Purity: >95% (NMR)
Appearance: White to off-white powder.
Solubility: Soluble in water (10 mg/ml) or DMSO (30mg/ml).
InChiKey: HKJKCPKPSSVUHY-GRTNUQQKSA-M
SMILES: C[N+]1(C)[C@@]([C@@]2([H])C(C=CC3=C4OCO3)=C4C(O2)=O)([H])C5=CC6=C(OCO6)C=C5CC1.[I-]
Description:
(-)-Bicuculline methiodide is the N-methylated water-soluble derivative of the widely-employed ionotropic GABAA receptor antagonist (+)-Bicuculline. This prototypic, competitive GABAA receptor antagonist displaces GABA from the agonist binding site to prevent receptor activation. It also acts as a negative allosteric inhibitor of channel opening to inhibit GABAA receptor activation by anaesthetic agents. Additionally it shows activity at SK calcium-activated potassium channels, nicotinic acetylcholine receptors and acetylcholinesterase. This compound reversibly and competitively blocks GABAA receptor mediated currents and is widely used to isolate glutamate receptor mediated EPSCs (excitatory postsynaptic potentials).
Size: 25mg,100mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.