bs-76091C

DATASHEET

Formulation Solid

Storage: Stable for 2 years after receipt when stored at +4°C.

Product Information:

CAS Number: 50-41-9

Molecular formula: C26H28ClNO . C6H8O7

Molecular weight: 598.08

Purity: >98% (HPLC)

Appearance: Solid.

Solubility: Soluble in DMOS or DMF. Slightly soluble in water, methanol or chloroform.

InChiKey: PYTMYKVIJXPNBD-BTKVJIOYSA-N

SMILES: Cl/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(CC)CC)C=C3.OC(CC(C(O)=O)(O)CC(O)=O)=O

SMILES: OC(=O)CC(O)(CC(O)=O)C(O)=O.CCN(CC)CCOC1=CC=C(C=C1)C(=C(Cl)C1=CC=CC=C1)C1=CC=CC=C1

Description:

Clomiphene is a nonsteroidal triphenylethylene derivative. It acts as a selective estrogen receptor modulator (SERM), that impairs the activation of estrogen receptors (ERs) by 17beta-estradiol, similar to tamoxifen and raloxifene. It potently binds both ERalpha and ERbeta (Ki = 0.9 and 1.2nM, respectively). Clomiphene enhances the release of gonadotropin-releasing hormone, stimulating the release of follicle-stimulating hormone and luteinizing hormone, culminating in ovulation. Triphenylethylene antiestrogens may also be used as antileukemic drugs which kill cells by apoptosis mediated by oxidative stress and activation of PKC.