bs-76092C
[Life Science]
Cabozantinib S-malate
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support@biossusa.com
800.501.7654 [DOMESTIC]
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support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation Powder
Storage: Stable for 2 years after receipt when stored at +4°C.
Product Information:
CAS Number: 1140909-48-3
Molecular formula: C32H30FN3O10
Molecular weight: 635.59
Purity: >99% (HPLC)
Appearance: White to off white crystalline powder.
Solubility: Soluble in DMSO.
InChiKey: HFCFMRYTXDINDK-WNQIDUERSA-N
SMILES: O=C(C1(CC1)C(NC2=CC=C(F)C=C2)=O)NC(C=C3)=CC=C3OC4=CC=NC5=CC(OC)=C(OC)C=C54.O=C(O)C[C@H](O)C(O)=O
SMILES: O[C@@H](CC(O)=O)C(O)=O.COC1=C(OC)C=C2C(OC3=CC=C(NC(=O)C4(CC4)C(=O)NC4=CC=C(F)C=C4)C=C3)=CC=NC2=C1
Molecular formula: C32H30FN3O10
Molecular weight: 635.59
Purity: >99% (HPLC)
Appearance: White to off white crystalline powder.
Solubility: Soluble in DMSO.
InChiKey: HFCFMRYTXDINDK-WNQIDUERSA-N
SMILES: O=C(C1(CC1)C(NC2=CC=C(F)C=C2)=O)NC(C=C3)=CC=C3OC4=CC=NC5=CC(OC)=C(OC)C=C54.O=C(O)C[C@H](O)C(O)=O
SMILES: O[C@@H](CC(O)=O)C(O)=O.COC1=C(OC)C=C2C(OC3=CC=C(NC(=O)C4(CC4)C(=O)NC4=CC=C(F)C=C4)C=C3)=CC=NC2=C1
Description:
The s-malate salt form of Cabozantinib is very potent orally available inhibitor of multiple receptor tyrosine kinases (RTK), specifically MET and VEGFR2. It also inhibits KIT, FLT3, Tie-2, RET and AXL. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature, angiogenesis and extensive tumor cell apoptosis.
Size: 100mg, 500mg, 1g
Applications: Life Science
For research use only. Not intended for diagnostic or therapeutic use.