bs-76096C

DATASHEET

Formulation Powder

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 117048-59-6

Molecular formula: C18H20O5

Molecular weight: 316.35

Purity: >98% (HPLC)

Appearance: Off-white powder.

Solubility: Soluble in DMSO (10mg/ml), ethanol (5mg/ml) or DMF (10mg/ml). Insoluble in water.

InChiKey: HVXBOLULGPECHP-WAYWQWQTSA-N

SMILES: OC1=CC(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)=CC=C1OC

SMILES: COC1=CC(\C=C/C2=CC(O)=C(OC)C=C2)=CC(OC)=C1OC

Description:

Combretastatin A4 is a natural stilbenoid phenol originally isolated from an African shrub, Combretum caffrum. It is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. It inhibits tubulin polymerization at the colchicine-binding site of beta-tubulin. CA4 was shown to impede tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-1 (pancreatic carcinoma) and MCF-7 (breast cancer). It has antitumor activity by inhibiting AKT function in human gastric cells. The inhibited AKT activation causes decreased cell proliferation, cell cycle arrest and reduced in vitro migration/invasiveness and in vivo metastatic ability. Combretastatin A-4 is the active component of combretastatin A-4 phosphate, a prodrug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis. Combretastatin A-4 is therefore a vascular disrupting agent (VDA) that targets tumor vasculature to inhibit angiogenesis.