bs-76165C

DATASHEET

Formulation Powder

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 20830-75-5

Molecular formula: C41H64O14

Molecular weight: 780.94

Purity: >95% (HPLC)

Appearance: White powder.

Solubility: Soluble in DMSO (100mM) or methanol.

InChiKey: LTMHDMANZUZIPE-PUGKRICDSA-N

SMILES: [H][C@@]1(C[C@H](O)[C@H](O[C@@]2([H])C[C@H](O)[C@H](O[C@@]3([H])C[C@H](O)[C@H](O)[C@@H](C)O3)[C@@H](C)O2)[C@@H](C)O1)O[C@H]1CC[C@@]2(C)[C@]([H])(CC[C@]3([H])[C@]2([H])C[C@@H](O)[C@]2(C)[C@H](CC[C@]32O)C2=CC(=O)OC2)C1

SMILES: C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@H]1[C@@H](O)C[C@H](O[C@H]2[C@@H](O)C[C@H](O[C@H]3CC[C@@]4(C)[C@H](CC[C@@H]5[C@@H]4C[C@@H](O)[C@]4(C)[C@H](CC[C@]54O)C4=CC(=O)OC4)C3)O[C@@H]2C)O[C@@H]1C

Description:

Cardiac glycoside from the leaves of Digitalis lanata. It is used to treat cardiac arrhythmias. It is often used as a model substrate of P-glycoprotein (Pgp) (0.01-10µM) and an inhibitor of Na+/K+-ATPase. Inhibits membrane-bound alpha-subunits of the Na+/K+ ATPase pump in myocytes. The primary mechanism of action involves inhibition of the Na+/K+ ATPase, mainly in the myocardium. This inhibition causes an increase in intracellular sodium levels, resulting in a reversal of the action of the sodium-calcium exchanger, which causes an increase in the intracellular calcium concentration. This leads to a decrease in heart rate and increased storage of calcium in the sarcoplasmic reticulum, causing a corresponding increase in the release of calcium during each action potential.