DATASHEET
Formulation
Powder
Storage:
Stable for 2 years after receipt when stored at -20°C.
Product Information:
CAS Number: 2022-85-7
Molecular formula: C4H4FN3O
Molecular weight: 129.09
Purity: >99% (TLC)
Appearance: White to off-white powder.
Solubility: Soluble in water.
InChiKey: XRECTZIEBJDKEO-UHFFFAOYSA-N
SMILES: NC1=NC(=O)NC=C1F
SMILES: NC1=NC(=O)NC=C1F
Description:
Fluorinated pyrimidine analog. Antimycotic prodrug that is converted by cytosine deaminase to 5-fluorouracil (a widely used cytotoxic drug) and further metabolized to fluorinated ribo- and deoxyribonucleotides. Inhibits DNA and RNA synthesis and interfers with ribosomal protein synthesis. Displays antifungal and antitumor activity. Lately with the development of gene therapy, it has been introduced as a prodrug in combination with the cytosine deaminase suicide gene as antitumor compound, significantly improving survival and reducing tumor size in selected tumors.