bs-76361C

DATASHEET

Formulation Powder

Storage: Stable for 2 years after receipt when stored at RT.

Product Information:

CAS Number: 59870-68-7

Molecular formula: C20H20O4

Molecular weight: 324.37

Purity: >98% (HPLC)

Appearance: White to light brown powder.

Solubility: Soluble in DMSO, ethanol or DMF (all 20mg/ml).

InChiKey: LBQIJVLKGVZRIW-ZDUSSCGKSA-N

SMILES: CC1(C)C=CC2=C(C=CC3=C2OC[C@@H](C4=C(O)C=C(O)C=C4)C3)O1

SMILES: CC1(C)OC2=C(C=C1)C1=C(C[C@@H](CO1)C1=C(O)C=C(O)C=C1)C=C2

Description:

Glabridin is a prenylated isoflavonoid found in licorice (Glycyrrhiza glabra L.) root extract that is reported to possess antiviral, antimicrobial, anti-inflammatory, antidiabetic, antiatherogenic, antioxidant, antitumor and estrogen-like properties. These diverse biological activities are largely related to the capacity of glabridin to down-regulate reactive oxygen species, bind to antioxidant effectors and act as a selective estrogen receptor modulator. On a molecular level it is, next to other targets, activating PPARgamma, inhibiting JNK1/2 and human carboxylesterase 2 (CES2A). Based on its antioxidant capacity it is also studied as an anti-aging cosmetic agent. Recently, it has been shown in docking experiments to have high binding affinity to the main protease of SARS-CoV-2.