DATASHEET
Formulation
Solid
Storage:
Stable for 2 years after receipt when stored at RT.
Product Information:
CAS Number: 130018-87-0
Molecular formula: C21H25ClN2O3 . 2HCl
Molecular weight: 461.81
Purity: >98% (HPLC)
Appearance: Solid.
Solubility: Soluble in water (20mg/ml).
InChiKey: PGLIUCLTXOYQMV-GHVWMZMZSA-N
SMILES: ClC(C=C1)=CC=C1[C@@H](C2=CC=CC=C2)[NH+]3CC[NH+](CCOCC(O)=O)CC3.[Cl-].[Cl-]
SMILES: Cl.Cl.OC(=O)COCCN1CCN(CC1)[C@H](C1=CC=CC=C1)C1=CC=C(Cl)C=C1
Description:
Levocetirizine hydrochloride is the (R)-enantiomer of the histamine H1 receptor antagonist and antihistamine agent cetirizine. It binds to the H1 receptor with higher affinity than cetirizine and is 25,000-100,000-fold selective for H1 receptors over muscarinic M1-M5 receptors. Intranasal administration dose-dependently decreases histamine-induced nasal rubbing and sneezing in mice. Has been used in the treatment of allergic rhinitis and chronic idiopathic urticaria.