bs-76495C

DATASHEET

Formulation Powder

Storage: Stable for 2 years after receipt when stored at +4°C.

Product Information:

CAS Number: 90-33-5

Molecular formula: C10H8O3

Molecular weight: 176.17

Purity: >95% (NMR)

Appearance: Beige powder.

Solubility: Soluble in DMSO (20mg/ml), ethanol (20mg/ml) or methanol (20mg/ml). Insoluble in water.

InChiKey: HSHNITRMYYLLCV-UHFFFAOYSA-N

SMILES: OC1=CC=C2C(OC(C=C2C)=O)=C1

SMILES: CC1=CC(=O)OC2=C1C=CC(O)=C2

Description:

4-Methylumbelliferone (4-MU) is a selective inhibitor of hyaluronan (HA) by depletion of UDP-glucuronic acid, the common substrate for HA synthesis and downregulation of hyaluronan synthase 2 and 3, MMP2 and MMP9. Since hyaluronan (HA) is a major component of the extracellular matrix that is synthesized in excess in cancer tissues, 4-MU has been shown to have anti-cancer activity and is involved in angiogenesis, invasion and metastasis of cancer. Fluorescent pH indicator, that is highly fluorescent in alkaline solution. Exhibits a blue fluorescence at pH7. The fluorescence intensity is pH dependent and increases to a maximum at pH10 (plateau above pH10). The fluorescence at pH10.3 is approximately 100 times as intense as at pH7. Spectral data: lambdaex=360nm; lambdaem=448nm; pH > 9. 4-Methylumbelliferone is an indicator also used in the determination of nitric acid and in 4-MU-O-substrates for the kinetic investigation of enzyme activity.