bs-76544C

DATASHEET

Formulation Powder

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 298-81-7

Molecular formula: C12H8O4

Molecular weight: 216.19

Purity: >95% (HPLC)

Appearance: White to yellow powder.

Solubility: Soluble in acetic acid or water (slightly).

InChiKey: QXKHYNVANLEOEG-UHFFFAOYSA-N

SMILES: COC1=C2OC=CC2=CC2=C1OC(=O)C=C2

SMILES: COC1=C2OC(=O)C=CC2=CC2=C1OC=C2

Description:

Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450). Has more potency than 5-MOP, 5-OH-P, DH-8-MOP and psoralen in inhibiting CYP2B1 (cytochrome P-450 2B1). Completely inhibits the metabolism of nicotine in vitro. Inhibits the metabolism of caffeine. Methoxsalen is a drug with photoactivating properties used to treat psoriasis, eczema, vitiligo and some cutaneous lymphomas in conjunction with exposing the skin to UVA light. Upon photoactivation, ultraviolet A (UVA) irradiation induces monoadducts and interstrand cross-links in DNA and therefore can be used to study DNA repair and recombination mechanisms.