DATASHEET
Formulation
Powder
Storage:
Stable for 2 years after receipt when stored at -20°C.
Product Information:
CAS Number: 1168-42-9
Molecular formula: C19H18O6
Molecular weight: 342.3
Purity: >95% (HPLC)
Appearance: White to yellow powder.
Solubility: Soluble in DMSO (20mg/ml) or chloroform.
InChiKey: URSUMOWUGDXZHU-UHFFFAOYSA-N
SMILES: O=C(C=C(C1=CC=C(OC)C=C1)O2)C3=C2C=C(OC)C(OC)=C3OC
SMILES: COC1=CC=C(C=C1)C1=CC(=O)C2=C(OC)C(OC)=C(OC)C=C2O1
Description:
Tetra-O-methylscutellarein is a bioactive component of Siam weed extract. It exhibits anti-inflammatory activity through inhibition of the NF-kappaB pathway. It suppressed IkappaB kinase complex alpha/beta (IKKalpha/beta) and Inhibitory-kappa-B-alpha (IkappaBalpha), inhibiting p65 translocation and thereby suppressing COX-2 and iNOS expression. This compound is modulating bacterial resistance to antimicrobial drugs most probably via efflux pump inhibition. It also showed anti-mutagenic activity.