bs-76571C

DATASHEET

Formulation Powder

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 86347-15-1

Molecular formula: C13H17ClN2

Molecular weight: 236.75

Purity: >98%

Appearance: White to off-white powder.

Solubility: Soluble in water (20mg/ml) or DMSO (20mg/ml).

InChiKey: VPNGEIHDPSLNMU-UHFFFAOYSA-N

SMILES: CC1=CC=CC(C(C)C2=CNC=N2)=C1C.Cl

SMILES: Cl.CC(C1=CNC=N1)C1=C(C)C(C)=CC=C1

Description:

Medetomidine is an imidazole derivative. It acts as a potent selective agonist of alpha2-adrenoceptors (Ki=1.08nM vs. 1750nM for alpha1-adrenoceptors). Through its effect on alpha2-adrenoceptors, medetomidine has sedative, antinociceptive, hypotenisve, bradycardic, anxiolytic, analgesic and hypothermic actions. Its effects on pain are additive or synergistic with fentanyl-type opioids. The effects of medetomidine are effectively countered by alpha2-adrenoceptor antagonists, like atipamezole. Selective alpha2-adrenoceptor agonists, including medetomidine, have anesthetic sparing properties, greatly reducing the dose of anesthetic required following premedication with the alpha2-adrenoceptor agonist.