bs-76667C

DATASHEET

Formulation Powder

Storage: Stable for 2 years after receipt when stored at +4°C.

Product Information:

CAS Number: 132539-06-1

Molecular formula: C17H20N4S

Molecular weight: 312.43

Purity: >98% (HPLC)

Appearance: Yellow powder.

Solubility: Soluble in DMSO (10mg/ml) or DMF.

InChiKey: KVWDHTXUZHCGIO-UHFFFAOYSA-N

SMILES: CN(CC1)CCN1C2=NC(C=CC=C3)=C3NC4=C2C=C(C)S4

SMILES: CN1CCN(CC1)C1=NC2=C(NC3=C1C=C(C)S3)C=CC=C2

Description:

Olanzapine is a 5-HT2 serotonin and D1/D2 dopamine receptor antagonist, that binds to dopamine D1, D2, and D4 receptors (Ki=31, 11, and 27 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2C and 5-HT3 (Ki=4, 11, and 57 nM, respectively). It also binds to M1 muscarinic acetylcholine, alpha1-adrenergic and histamine H1 receptors (Ki=2, 19, and 7 nM, respectively). Olanzapine is an atypical antipsychotic that displays anticholinergic properties. Olanzapine shows antidepressant-like activity. Formulations containing olanzapine have been used in the treatment of schizophrenia and bipolar disorder and for the prevention and treatment of chronic nausea and chemotherapy-induced nausea and vomiting.