bs-76678C

DATASHEET

Formulation Powder

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 17695-48-6

Molecular formula: C26H38O4

Molecular weight: 414.59

Purity: >95% (NMR)

Appearance: White to off-white crystalline powder.

Solubility: Soluble in DCM (10mg/ml), chloroform (20mg/ml) or DMF (10mg/m).

InChiKey: QKQVFFACWLFRRX-UHFFFAOYSA-N

SMILES: O=C1OC2=CC(OC(CCCCCCCCCCCCCCC)=O)=CC=C2C(C)=C1

SMILES: CCCCCCCCCCCCCCCC(=O)OC1=CC2=C(C=C1)C(C)=CC(=O)O2

Description:

4-Methylumbelliferyl palmitate (4-MUP) is a fluorogenic substrate for lysosomal acid lypase (LAL). 4-MUP is cleaved by LAL (or by other acid lipases) to release the fluorescent moiety 4-MU. Recent advances allow the assessment of LAL activity in very small blood volumes using 4-MUP. Cholesterol ester storage disease and Wolman disease are recessive autosomal disorders caused by a deficiency in lysosomal acid lipase (LAL), also known as cholesteryl ester hydrolase. Spectral data: 4-MU fluorescence is pH-dependent. lambdaex 320nm (pH 1.97-6.72) and 360nm (pH 7.12-10.3); lambdaem 445-455nM (increasing as pH decreases).