bs-76687C
[Life Science]
5-[(4-Propyloxyphenyl)methylene] 2,4-thiazolidinedione
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support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation Powder
Storage: Stable for 2 years after receipt when stored at -20°C.
Product Information:
CAS Number: 587852-28-6
Molecular formula: C13H13NO3S
Molecular weight: 263.3
Purity: >95% (HPLC)
Appearance: Yellow powder.
Solubility: Soluble in DMSO.
InChiKey: GBWOSXZUTXXXQF-FLIBITNWSA-N
SMILES: CCCOC1=CC=C(\C=C2/SC(=O)NC2=O)C=C1
Molecular formula: C13H13NO3S
Molecular weight: 263.3
Purity: >95% (HPLC)
Appearance: Yellow powder.
Solubility: Soluble in DMSO.
InChiKey: GBWOSXZUTXXXQF-FLIBITNWSA-N
SMILES: CCCOC1=CC=C(\C=C2/SC(=O)NC2=O)C=C1
Description:
Potent, cell-permeable, ATP-competitive inhibitor of Pim-1/2 kinases (IC50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively) as well as DYRK1alpha (68% inhibition of DYRK1alpha and Pim-2 at 5 µM), while exhibiting little or no activity against a panel of 57 other kinases (<18% inhibition at 5 µM). Reported to exhibit antitumor activity in PC3 human prostate cancer cultures in vitro (IC50 = 48 µM) and in JC adenocarcinoma-transplanted Balb/C mice in vivo (~46% tumor mass reduction on day 20| 50 mg/kg via daily i.p.).
Size: 5mg,10mg,50mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.