bs-76726C

DATASHEET

Formulation Powder

Storage: Stable for 2 years after receipt when stored at +4°C.

Product Information:

CAS Number: 60-82-2

Molecular formula: C15H14O5

Molecular weight: 274.27

Purity: >98% (HPLC)

Appearance: White to off-white powder.

Solubility: Soluble in DMSO, ethanol or methanol. Insoluble in water.

InChiKey: VGEREEWJJVICBM-UHFFFAOYSA-N

SMILES: Oc1ccc(CCC(=O)c2c(O)cc(O)cc2O)cc1

SMILES: OC1=CC=C(CCC(=O)C2=C(O)C=C(O)C=C2O)C=C1

Description:

Phloretin is a natural dihydrochalcone, originally identified from the apple tree, and is a metabolite of phlorizin. It has numerous pharmacological effects, including anti-inflammatory, antidiabetic, anticancer, antimicrobial, hepatoprotective, neuroprotective and cytoprotective properties. Phloretin is a potent antioxidant, scavenging peroxynitrite (ONOO-) and/or suppressing lipid peroxidation, which contributes to the many biological properties. Phloretin has anti-aging and depigmenting effects, making it also attractive for dermatological research and application. Phloretin attacks a number of molecular targets, modulating different intracellular signaling pathways, including NF-kappaB, MAPK, Nrf2, and AMPK. It can modulate Ca2+ channels, PKC, GLUTs, SGLTs and other targets. The anticancer potential is based on antiproliferative, proapoptotic, antimetastatic, and antiangiogenic activities.