bs-76790C

DATASHEET

Formulation Powder

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 79559-97-0

Molecular formula: C17H17NCl2 . HCl

Molecular weight: 342.69

Purity: >98% (HPLC)

Appearance: White to off-white powder.

Solubility: Soluble in DMSO (20mg/ml) or ethanol (10mg/ml).

InChiKey: BLFQGGGGFNSJKA-XHXSRVRCSA-N

SMILES: ClC(C=C1)=C(Cl)C=C1[C@H]2C3=C(C=CC=C3)[C@@H]([NH2+]C)CC2.[Cl-]

SMILES: Cl.CN[C@H]1CC[C@@H](C2=CC(Cl)=C(Cl)C=C2)C2=C1C=CC=C2

Description:

Sertraline is a tetraline that inhibits monoamine transporters and acts as a potent highly selective serotonin reuptake inhibitor (SSRI), with affinity for the serotonin transporter (SERT), increasing availability of serotonin (5-hydroxytryptamine; 5-HT) in the brain and leading to antidepressant, anxiolytic and antiobsessional effects. Sertraline binds also to the dopamine transporter (DAT) and the sigma1 receptor (but not the sigma2 receptor) with 100-fold lower affinity. It acts as an antagonist of the sigma1 receptor, and is able to reverse sigma1 receptor-dependent actions of fluvoxamine, a potent agonist of the receptor, in vitro. Sertraline displays antiproliferative activity on human colorectal carcinoma cells.