bs-76794C

DATASHEET

Formulation Powder

Storage: Stable for 2 years after receipt when stored at RT.

Product Information:

CAS Number: 54-21-7

Molecular formula: C7H5O3 . Na

Molecular weight: 160.1

Purity: >99% (dried substance)

Appearance: White to off-white crystalline powder.

Solubility: Soluble in water (50mg/ml) or ethanol.

InChiKey: ABBQHOQBGMUPJH-UHFFFAOYSA-M

SMILES: OC1=C(C(O[Na])=O)C=CC=C1

SMILES: [Na+].OC1=C(C=CC=C1)C([O-])=O

Description:

Sodium salicylate is a metabolite of aspirin. It is a cell-permeable, non-steroidal anti-inflammatory agent (NSAID) that interferes with TNF-induced NF-kappaB activation by inhibiting phosphorylation and subsequent degradation of the IkappaB-alpha protein. It selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases and TNF-induced activation of JNK. It induces apoptosis via p38 kinase activation and inhibits COX-2 and inducible NOS (iNOS) transcription dependent on the experimental setup. It is commonly used for its antipyretic, anti-oxidant, neuroprotective, anti-inflammatory, anti-cancer and analgesic properties.