bs-76799C

DATASHEET

Formulation Powder

Storage: Stable for 2 years after receipt when stored at +4°C.

Product Information:

CAS Number: 808-26-4

Molecular formula: C21H22N2O7

Molecular weight: 414.4

Purity: >98% (HPLC)

Appearance: Yellow to green powder.

Solubility: Soluble in DMSO.

InChiKey: XDVCLKFLRAWGIT-ADOAZJKMSA-N

SMILES: OC1=C2C(C[C@]3([H])C(C2=O)=C(O)[C@@]4(O)[C@@]([C@H](N(C)C)C(O)=C(C(N)=O)C4=O)([H])C3)=CC=C1

SMILES: CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=CC=CC(O)=C4C(=O)C3=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O

Description:

Sancycline is a semisynthetic tetracycline antibiotic that is more active than tetracycline against 339 strains of anaerobic bacteria (average MIC90s = 1 and 32 µg/ml, respectively). Sancycline is active against tetracycline-resistant E. coli, S. aureus, and E. faecalis strains with MICs ranging from 0.06 to 1 µg/ml. In vivo, sancycline is active against S. aureus in mice with ED50 values of 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration, respectively. Like other tetracyclines, sancycline acts by reversibly binding to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site.