bs-7855R [Primary Antibody]
AICDA Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: AICDA

Immunogen Range: 101-198/198


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 57379

Swiss Prot: Q9GZX7

Source: KLH conjugated synthetic peptide derived from human AICDA

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Background:

Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 24


Predicted Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Demberg, Thorsten, et al. "Loss of marginal zone B-cells in SHIV SF162P4 challenged rhesus macaques despite control of viremia to low or undetectable levels in chronic infection." Virology 484 (2015): 323-333.Read more>>
  • Carlos E. Rivera. et al. Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells. SCI ADV. 2023 Apr;9(17)Read more>>
VALIDATION IMAGES

Lane 1: Human Raji cell Lysates; Lane 2: Human HepG2 cell Lysates; Lane 3: Human Hela cell Lysates. Probed with AICDA polyclonal Antibody, unconjugated (bs-7855R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.