bs-82065C

DATASHEET

Formulation White Solid

Storage: -20°C

Product Information:

Zileuton is a reversible inhibitor (IC50 = 500nM RBL-1 cells, 300nM rat PMNL cells) of 5-Lipoxygenase (5-LO).1 It also inhibited leukotriene B4 biosynthesis (IC50’s = 400nM rat PMNL, 400nM human PMNL and 900nM human whole blood).1 Zileuton suppressed prostaglandin biosynthesis via interference with arachidonic acid release in macrophages independent of 5-LO inhibition (IC50 = 13 µM PGE2 inhibition in LPS-stimulated whole blood).2 Zileuton was approved by the FDA in 1997 for the treatment of asthma (ZYFLO).

Description:

CAS Number: 111406-87-2; Chemical Name: N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea; Molecular weight: 236.29; Formula: C11H12N2O2S; Solubility: DMSO (25 mg/ml); Physical Properties: white solid; Purity: >98%, NMR (Conforms)

Size: 10mg, 50mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.